Postdoctoral Fellow

City of Hope

Duarte, CA

ID: 7055168
Posted: January 9, 2019
Application Deadline: Open Until Filled

Job Description

About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary
The Beckman Research Institute of City of Hope is looking for talented Postdoctoral Fellows who will be in the laboratory of Dr. Yilun Liu at the Department of Cancer Genetics and Epigenetics. The focus of the lab relates to the studies of the molecular functions of a group of tumor suppressors known as the human RECQ family helicases. Mutations in different RECQ proteins have been linked to distinct clinical syndromes with various developmental abnormalities, premature aging phenotypes and cancer predisposition.

Works from Dr. Liu’s laboratory have established novel models and important mechanistic insights into (a) how Rothmund-Thomson syndrome helicase, RECQ4, facilitates efficient nuclear and mitochondrial DNA replication; (b) how mutations in RECQ4 contribute to cancer pathogenesis; (c) how tumor suppressor RECQ5 avoids detrimental DNA damages caused by transcription; and (d) how RECQ5 provides chemo-resistance to Topoisomerase 1-targeting therapy. These findings were published in journals, including Nature Communications, Cell Reports, EMBO Journal and PNAS. Please visit for a full list of publications from Dr. Liu’s laboratory.

Basic education, experience and skills required for consideration:
 A Ph.D. degree in life or biomedical sciences, or a related discipline is required.

Preferred education experience and skills:
 Experience in biochemistry and/or cell biology is preferred.

Additional Information:
 For more information on the RECQ helicases and the related research from Dr. Liu’s laboratory, please visit

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


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