Postdoctoral Fellow - Dr. Wantong Yao laboratory - Dept of Translational Molecular Pathology at MDACC

The University of Texas M. D. Anderson Cancer Center

Houston, TX

ID: 7057484
Posted: May 29, 2019
Application Deadline: Open Until Filled

Job Description

The Wantong Yao laboratory at MD Anderson
Cancer Center is recruiting exceptional national
and international post-doctoral fellows and
students. We are seeking outstanding and
motivated individuals who will join us in our quest
to investigate therapeutic vulnerabilities and
understand molecular implication of pancreatic
cancer.
Our research is focused on identifying context-specific druggable vulnerabilities
required for oncogenic signaling and function, with a specific interest in surface
proteins. We aim to gain deep molecular insights into the complicated array of
oncogene-dependent and -independent events driving tumor progression to
discover novel therapeutic approaches that target mechanism essential for cancer
cell survival. We are currently using proteomic, genetic, molecular biological as well
as biochemical technologies to identify context-specific druggable vulnerabilities
required for oncogenic function in preclinic model system, such as genetically
engineered mouse model and patient derived xenograft model. We have been
focusing on gaining deep molecular insights into the complicated array of oncogenic
Kras-dependent (published in Nature, 2019) and –independent (published in Cell,
2014) events driving tumor progression to discover novel therapeutic approaches
that target mechanism essential for cancer cell survival. A few potential projects
are:
1) Apply an in-house unbiased integrated target-discovery platform to identify
novel therapeutic susceptibilities for pancreatic cancer and its environment
2) Dissect the detailed molecular mechanisms by which the identified novel
targets regulate cancer cells and immune cells
3) Determine the cancer preventive impact of the genetic and pharmacological
interruption of pro-cancerous events, Kras signaling and inflammation, on
pancreatic cancer development and maintenance
4) Elucidate functional and targetable players of oncogene-dependent and -
independent events in metabolic reprogramming, metastasis as well as drug
resistance
Postdoctoral fellows and students joining the lab would also join a wide
collaboration network across MD Anderson and other institutions. A tutorial in my
laboratory will provide mentoring and hands-on experience with extensive training
in topics and basic/advanced techniques that will be imperative for initiating a
successful independent research career. The long-term goal of our laboratory is to
build up a highly successful research team and work closely with fellow scientists
and physicians to continue exploring the basic and translational problems of human
cancer disease.

M. D. Anderson Cancer Center is an equal opportunity employer and does not discriminate on basis of race, color, national origin, gender, sexual orientation, age, religion, disability or veteran status except where such distinction is required by law. All positions at The University of Texas M. D. Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.



 

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