ID: 7057719 (Ref.No. 312026KP)
Posted: June 13, 2019
Application Deadline: Open Until Filled
A Postdoctoral Associate position is available in a laboratory interested in the role of glycosylation and deglycosylation in animal development and human disease. The lab uses cell culture, Drosophila and mouse genetics to identify and characterize genetic modifiers of human disease genes, in hopes of shedding light on disease pathophysiology and establishing new therapeutic targets. The lab staff closely collaborate with experts in carbohydrate biochemistry. The lab has reported a mouse model for a developmental disorder called Alagille syndrome (ALGS; OMIM 118450), and identified a glycosyltransferase called Poglut1 as a dominant genetic suppressor of the biliary phenotypes in this ALGS model (Thakurdas et al, Hepatology, 2016). Have also identified a transcription factor as a dominant modifier of the disease phenotypes, whose expression also shows a strong correlation with liver disease severity in human patients (unpublished data).
- Building on these observations, the postdoctoral associate will examine the genetic and transcriptional network involved in ALGS liver abnormalities and will examine the potential utility of these observations for developing therapies for this disease. These studies are likely to provide fundamental insights into normal biliary development and biliary repair in disease contexts.
Required: PhD in biomedical science or equivalent
- Experience in mouse genetics and mammalian cell culture is essential.
- Expertise in molecular biology and biochemistry is highly desired.
- The ideal candidate will be a highly motivated and have a strong publication record.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.