ID: 7057888 (Ref.No. 304832DP)
Posted: June 14, 2019
Application Deadline: Open Until Filled
We are seeking a highly motivated individual for a Staff Scientist within the Laboratory for Regenerative Tissue Repair at the Baylor College of Medicine. The laboratories within the center perform basic, translational, and pre-clinical. The position currently available is to study the current research aims to study the effect of altered fluid shear forces on the cell biology of the LVOT endocardia endothelium that results in a progressive fibroplasia. Surgery is invariably performed on these patients to remove the fibrotic tissue (formed at LVOT), which is successful in some patients, whereas others develop a recurrence and go on to needing additional correctional surgeries. There could be several factors predisposing these patients, including previous congenital heart surgeries that result in changes in geometry and therefore fluid forces, genetic factors, and environmental factors. We are looking to hire a staff scientist (MD/PhD) who can lead the project. This individual should be able to lead the current studies as well as develop additional lines of investigation that will utilize our large biobank of DSS patient derived tissue and blood samples, clinical echocardiography and omics analysis to further improve our understanding of this pathologic condition. The staff scientist is also expected to lead the team of graduate students and research technicians in the lab investigations and help in publishing the findings and grant writing. In addition to lab techniques, the ideal candidate will have a strong background in: • Excellent influencing and problem solving skills, as well as the confidence to work independently with interdisciplinary group of scientists, physicians and engineers • A proven record of publications in peer-reviewed journals and Presentations at scientific conferences.
- Ph.D. and/or M.D.
- At least 5 years of prior lab experience and familiarity with molecular and cellular biology techniques.
- An understanding of biochemistry, genetics and cell and molecular biology are preferred.
- Genetic perturbation techniques: CRISPR/Cas9, shRNA, etc. are preferred.
- Prior work with small animal model systems preferred.
- Practical experience of fluorescence/luminescence-based cell reporter assays is preferred.