Research Fellow in Enamel Protein Biochemistry

University of Leeds

Leeds, United Kingdom

ID: 7060124 (Ref.No. MHDEN1158)
Posted: September 6, 2019

Job Description

Are you interested in normal and pathological function of proteins involved in enamel biomineralisation? Do you have skills in protein biochemistry techniques and analyses? Would you like to join a multidisciplinary team using and developing protein purification and binding methods to investigate the role of amelogenin proteins in dental enamel biomineralisation?

This is an excellent opportunity for you to join a new team led by Professor Maisoon Al-Jawad to work on an exciting project in the Department of Oral Biology within Leeds School of Dentistry. As part of a multidisciplinary team you will be using methods for production and purification of recombinant amelogenin, and use in vitro biophysical techniques to explore protein binding and aggregation.

Previously, it has been shown that a point mutation (related to human X-linked Amelogenesis Imperfecta), causes amelogenin protein to aggregate intracellularly and fail to be expressed into the extracellular matrix where it is needed to fulfil its function during enamel biomineralisation. This project involves the use of in vitro methods to allow the determination of the mechanism by which this mutation causes excessive intracellular aggregation, and to explore how this aggregation affects protein-mineral binding. 

You will have, a PhD,(or close to completion, meaning, submitted initial version of thesis at point of application) and will have a first degree in biochemistry or related discipline. You will also have experience of working both independently and as part of multidisciplinary teams. Excellent interpersonal and communication skills are essential.

To explore the post further or for any queries you may have, please contact: 

Professor Maisoon Al-Jawad, Dept of Oral Biology, School of Dentistry

Email: m.al-jawad@leeds.ac.uk 


Further Information: 

The University of Leeds is committed to providing equal opportunities for all and offers a range of family friendly policies. The University is a charter member of Athena SWAN and holds the Bronze award. The School of Dentistry gained the Silver award in October 2017. We will be happy to consider job share applications and are committed to flexible working for all our employees.

Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Medicine & Health
School/Institute:  School of Dentistry
Section:  Department of Oral Biology
Category:  Research
Grade:  Grade 7
Salary:  £33,797 to £40,322 p.a.
Working Time:  Full time
Post Type:  Full Time
Contract Type:  Fixed Term (12 months - specific project for a limited period)
Release Date:  Friday 06 September 2019
Closing Date:  Sunday 06 October 2019
Reference:  MHDEN1158




 

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