POSTDOCTORAL RESEARCH FELLOW

The University of Texas MD Anderson Cancer Center

Houston, TX

ID: 7062509
Posted: November 27, 2019
Application Deadline: Open Until Filled

Job Description

Postdoctoral positions are available in the laboratory of Dr. Helen Piwnica-Worms at The University of Texas MD Anderson Cancer Center. The laboratory focuses on identifying alterations with functional significance to the development and progression of breast cancer and translating results from basic, omic and preclinical studies into improved clinical interventions for cancer patients.

A major effort is directed towards elucidating the contribution made by heterogeneity (genomic, phenotypic, spatial and compositional) in both the tumor and its microenvironment to cancer progression and response to therapy. Technologies include single cell RNA sequencing, ATAC-Seq, and imaging mass cytometry (IMC). Experimental models include human tumor tissue, PDX models of breast cancer and engineered mouse models.

Interested applicants should submit a cover letter specifying past accomplishments, a curriculum vitae, and the contact information of three references to: hpiwnica-worms@mdanderson.org

Representative recent publications:

• PMID:29736411: A functional genomic screen in vivo identifies CEACAM5 as a clinically-relevant driver of breast cancer metastasis. NPJ Breast Cancer. 2018.

• PMID:30194658: Intratumoral heterogeneity in ductal carcinoma in situ: chaos and consequence. J Mammary Gland Biol Neoplasia, 2018.

• PMC6265294: High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer. Nature Communications, 2018.

• Neoadjuvent Talazoparib for patients with operable breast cancer with a germline BRCA pathogenic variant. J. Clin. Oncol 2019.

• PMC6541393: Resistance to neoadjuvant chemotherapy in triple negative breast cancer mediated by a reversible drug-tolerant state, Science Translational Medicine, 2019.

M. D. Anderson Cancer Center is an equal opportunity employer and does not discriminate on basis of race, color, national origin, gender, sexual orientation, age, religion, disability or veteran status except where such distinction is required by law. All positions at The University of Texas M. D. Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.



 

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