Research Associate I - Lymphoma Translational Research

City of Hope

Duarte, CA

ID: 7062531 (Ref.No. 10004719)
Posted: November 25, 2019
Application Deadline: Open Until Filled

Job Description

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

Dr. Danilov's laboratory investigates mechanisms of drug resistance in B-cell malignancies. Lymph nodes and bone marrow are sites where neoplastic B-cells are exposed to cellular and acellular components of the microenvironment, which deliver pro-survival stimuli. Dr. Danilov's laboratory has a particular focus on the role of nuclear factor-kappaB signaling in this setting, and how this signaling can be targeted. In addition to a variety of in vitro models of the stromal niche, Dr. Danilov's laboratory models those conditions in vivo. Most recently, his laboratory has identified several promising strategies to inhibit stromal niche support via targeting proteasome-ubiquitin system responsible for protein degradation. Dr. Danilov's research is highly translational and involves work with primary samples from patients with chronic lymphocytic leukemia and lymphoma. Based on laboratory findings, Dr. Danilov's group originates early-phase clinical trials, allowing for verification of laboratory findings in the clinical setting. Dr. Danilov and his group present their work annually at the American Society of Hematology Meeting, as well as at specialty group meetings.

Key Responsibilities include:
  • A successful candidate will conduct experiments as defined in the research plan and will serve on a research team involved in the investigation of targeting the NF-kappaB pathway in lymphomas

Basic education, experience and skills required for consideration:

  • Bachelor's degree in a scientific discipline or related field.
  • 0-2 years of research/laboratory experience
  • Ability to prioritize multiple tasks at one time
  • Must have excellent communication, analytical and organizational skills: both written and verbal
  • Ability to work independently and as part of a team while being collaborative in resolving problems.
  • Must be proficient with computers running Windows and PC applications e.g. MS Excel, Oracle, Access, Word and PowerPoint)
  • Must have demonstrated excellent customer service skills both on the phone and in person
  • Must possess energy and drive to coordinate multiple projects simultaneously
  • Ability to use tact and diplomacy to maintain effective working relationships
  • Molecular Biology experience preferred

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


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