Research Associate Staff In Cancer Immunology

Cleveland Clinic

Cleveland, OH

ID: 7062972
Posted: January 9, 2020
Application Deadline: Open Until Filled

Job Description

A Research Associate staff level position is available in Dr. Li Lily Wang’s laboratory, in the Department of Translational Hematology Oncology Research (THOR), https://www.lerner.ccf.org/thor/wang/  in the Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH. The Wang laboratory is engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI /CCF and the Case Comprehensive Cancer Center, affiliated with Case Western Reserve University.

Immune-checkpoint blockade (ICB) therapies have revolutionized the field of Cancer Immunotherapy. However, the low response rate in a majority of patients indicates the urgent need to identify and target additional checkpoint regulators. The Wang laboratory is among the first group to demonstrate that the immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) is a promising target for cancer immunotherapy (1 – 6). Our studies show that VISTA regulates the effector functions of cytotoxic T cells, myeloid-derived suppressor cells (MDSC), and myeloid inflammatory DCs. Current projects are focusing on elucidating the molecular signaling mechanisms of VISTA and design innovative approaches to target this checkpoint protein for cancer therapy.

We seek talented and committed candidates with relevant experience and a Ph.D. in Biochemistry, Cell Biology, Immunology, or other relevant branches of biological sciences to join our team and make significant contributions to the field of Cancer Immunotherapy. Interested candidates should submit CV, a statement of research interests in a cover letter, and three references to Dr. Li Lily Wang, wangl9@ccf.org.



Cleveland Clinic is pleased to be an equal employment/affirmative action employer: Women/Minorities/Veterans/Individuals with Disabilities. Smoke/drug free environment.



 

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