Posted: January 28, 2020
Application Deadline: Open Until Filled
Investigating Chromatin Dysregulation due to Aberrant Dioxygenase Function in Human Pathology
A postdoctoral fellowship position is available in Dr. Abhishek Chakraborty’s newly established laboratory in the Department of Cancer Biology at the Cleveland Clinic, with an anticipated start date in the Fall of 2020. The laboratory is part of Cleveland Clinic’s Genitourinary (GU) Malignancies Research Center and has close ties to both basic researchers as well as GU clinicians at the Cleveland Clinic and the broader Case Comprehensive Cancer Center.
The laboratory is interested in the relevance of oxygen- (and 2-oxo-glutarate) dependent dioxygenases in cellular physiology, particularly in oxygen sensing and human disease. The laboratory is especially interested in studying the oxygen-dependent JmjC histone demethylases (e.g. KDMs) to 1) fundamentally understand the regulation and biological importance of hypoxia-dependent changes in chromatin; and 2) exploit dioxygenase dysfunction to identify therapeutically targetable vulnerabilities in human cancer, particularly kidney cancer.
The techniques/areas of interest in the laboratory are Biochemistry [Protein purification and Enzymatic Assays], Molecular Biology [Cloning, Western Blotting, etc], Proteomics, Cancer Biology [in vitro and in vivo tumor models], Cellular Metabolism [steady state and flux-balance analysis], Pharmacology [drug discovery and delivery], Genomic analysis [RNA-Seq and ChIP-Seq data], Genetic Screens [CRISPR/Cas9 and ORF-based libraries], and Pharmacological Screens [Drug-based libraries].
The ideal candidate would have a M.D., Ph.D., or M.D./Ph.D. degree with interests and expertise in one or more of these areas. We desire a self-motivated candidate with a collaborative and collegial work ethic, a strong commitment to basic cancer research, and outstanding verbal and communication skills.
The position will provide a unique and multidisciplinary exposure to study chromatin function, tumor metabolism, molecular oncology, drug development, and clinical collaborations, in a world class clinical/research center.
Candidates with an interest in the position should email their CV and contact information for 3 references to:
Abhishek A. Chakraborty, Ph.D.
Cleveland Clinic is pleased to be an equal employment/affirmative action employer: Women/Minorities/Veterans/Individuals with Disabilities. Smoke/drug free environment.