Postdoctoral Fellowships in Chromatin structure and function, Cancer epigenetics

The University of Texas MD Anderson Cancer Center

Smithville, TX

ID: 7065220
Posted: March 10, 2020

Job Description

We are accepting applications for postdoctoral fellows interested in the study of ATP-dependent chromatin remodelers and their regulation of gene expression, chromatin dynamics and nuclear architecture. ATP-dependent chromatin remodelers are gatekeepers of the cell and are crucial for maintaining pluripotency as well as for differentiation with mutations of these remodelers causing cancer and other diseases. We use mouse embryonic stem cells and yeast as our model systems along with cutting-edge genomics, structural and chromatin biology to uncover the molecular basis of these chromatin remodelers in cellular development/differentiation and oncogenesis.

One project is studying the structure and function of the INO80 chromatin remodeler, its role in chromatin dynamics and exchange of histone variants. Another of our projects is on the SWI/SNF chromatin remodeler and how cancer associated mutations might impact its role in promoting differentiation versus de-differentiation/pluripotency through regulation of RNA polymerase II pausing and long-range chromatin interactions. These are NIH-funded project in the laboratory of Blaine Bartholomew. These positions require a Ph.D. and expertise in cell/molecular biology, biochemistry and bioinformatics. Applications should include a cover letter describing your goals/plans, major achievements and skills; your CV and have contact information for at least three references to bbartholomew@mdanderson.org. For more information about our laboratory please see the following websites:
https://www.mdanderson.org/research/departments-labs-institutes/labs/bartholomew-laboratory.html
https://www.mdanderson.org/research/departments-labs-institutes/labs/bartholomew-laboratory/research.html

Our laboratory is in the Department of Epigenetics and Molecular Carcinogenesis at the University of Texas MD Anderson Cancer Center and we are part of the Center for Cancer Epigenetics at MD Anderson Cancer Center.

Diversity and inclusion at MD Anderson are not just important; they are essential. We take an expansive view of diversity, considering differences in race, ethnicity, sexual orientation, gender and religious beliefs, as well as communication styles, thought, skill and ambition. We constantly examine our culture to create an inclusive working environment that effectively attracts, retains, develops and utilizes the skills and talents of all employees. Our Diversity Council develops strategies to attract and retain superior talent and enhance workforce diversity and inclusion. We also offer multiple diversity training programs to our employees.



 

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