Modeling Intestinal Diseases and Therapeutic Responses in Human Organ Chips – Postdoctoral Fellow

The Wyss Institute for Biologically Inspired Engineering at Harvard University

Boston, MA

ID: 7070447
Posted: September 30, 2020
Application Deadline: Open Until Filled

Job Description

The Wyss Institute for Biologically Inspired Engineering at Harvard University invites applications for a postdoctoral fellow position in the Biotherapeutics and Diagnostics platform. The mission of the Wyss Institute is to discover the engineering principles that Nature uses to build living things; to pursue the high-risk research that is fundamental to advance this effort; and to harness these insights to create biologically-inspired technological innovations to advance human health and improve the environment – thereby revolutionizing clinical medicine and creating a more sustainable world.

We seek outstanding postdoctoral applicants with expertise in microbiome research to join an interdisciplinary team of biologists and engineers for the development of novel in vitro organ-on-a-chip (Organ Chip) microfluidic culture systems and sensor technologies to study and model the intestinal tract and microbiome and its influences on diseases, such as malnutrition-associated with environmental enteric dysfunction (EED), inflammatory bowel disease (IBD), and radiation-induced injury, as well as therapeutic responses. Applicants are expected to hold a Ph.D. or M.D. and have a proven record of high quality publications in microbiology and/or microbiome research. Strong interest in contributing to multidisciplinary teams (engineers, biologists/physiologists, clinicians) is critical for this position. Expertise in in vitro culture of primary human cells, as well as knowledge of basic molecular and cell biology concepts and techniques is a plus. Significant skill in the culture, quantification and characterization of whole human microbiome and microbiology techniques is necessary.

The ideal candidate would bring expertise in microbiology and/or intestinal cell biology, inflammation, microbiology, physiology, and pathophysiology, with an interest in applying this expertise in combination with modern bioengineering practices. This postdoctoral fellow is expected to develop and lead an interdisciplinary research project aimed at exploring host responses to changes in microbiome using a microengineered Organ Chip models that simulate diseases, such as EED, IBD, and radiation injury as well as exploring responses to possible interventions and pursuing mechanisms of efficacy.

Applications, assembled as single PDF files, should contain a complete resume, cover letter describing research interests and goals, full list of publications, copies of up to three relevant scientific papers, as well as the names and contact information of three references (expected to provide letters of recommendation). Applications should be sent to using the subject line “INTESTINAL CHIP APPLICATION.”

Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Demonstrates a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.


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