Postdoctoral Fellow - Protein Engineering - Williams Lab

City of Hope

Duarte, CA

ID: 7070573 (Ref.No. 10004788rxv_113_1)
Posted: October 3, 2020
Application Deadline: Open Until Filled

Job Description

About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary
The Williams lab is looking for a Postdoctoral Fellow interested in seeing their efforts translated to the clinic to treat cancer and diabetic patients. The position involves an atoms-up approach to design novel biologics to mitigate on-target, off-tissue toxicities and improve their therapeutic efficacy. The requisite research includes the application of structural biology, computation, biophysics, in vitro and in vivo assays while communicating and coordinating these efforts with the rest of the team and clinicians at City of Hope focusing on immediate clinical needs. The successful candidate will be deeply involved through all aspects of this bench-to-bedside approach.
The Williams lab is equipment with state-of-the-art instruments including multiple incubators, biosafety cabinets, multiple FPLCs (including a new Biorad NGC FPLC – automating the purification of dozens of molecules per day), an Agilent HPLC, Biacore T200, Waters nanoITC, Beckman XLI, Mosquito crystallization robot, Formulatrix imagers, and a Rigaku 007HF diffractometer. A new Sony SH800 cell sorter is also located in the lab to further drive these efforts using novel display libraries developed in-house. In addition, the successful candidate will have access to 27 core facilities across the campus.

Basic education, experience and skills required for consideration:
  • PhD in chemistry, biochemistry, protein chemistry, biochemical engineering or related field with 1 to 3 years of postdoctoral experience
  • Experience with protein expression and purification
  • Fully versed in protein purification methods (Affinity, SEC, IEX), analysis (e.g., SDS-PAGE)
  • Experience with cell culture (E. coli and CHO a must, yeast and insect desirable). Experience with SPR and other biophysical methods desirable
  • Protein engineering, production, purification in CHO
  • Biophysical characterization (SPR, ITC, AUC, CD)
  • X-ray Crystallography
  • Assay development, interpretation, and troubleshooting
  • Excellent written and verbal communication skills
  • Good problem solving skills
  • Ability to conduct independent research
  • Ability to supervise others and work effectively in a team

Preferred education, experience and skills:
  • Enzymology experience a plus
  • CryoEM experience a plus

Additional Information:
City of Hope is a world leader in translational medicine, including synthesis of first synthetic gene, humanization of monoclonal antibodies and pioneering work in CAR T cells. These discoveries have led to some of the most important therapeutics in world including recombinant insulin for maintenance of type 2 diabetes and Rituxan, Herceptin, Avastin, etc. for the treatment of cancer. Building off these successes, City of Hope houses three FDA approved GMP facilities along with its 27 core facilities to rapidly advance discoveries.
  • For more information about Dr. Williams' research, please click here .
  • Please note, this is one of three Postdoctoral Fellowships available in Dr. Williams' lab.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.


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