ID: 7071102 (Ref.No. 959a612c)
Posted: October 17, 2020
Application Deadline: Open Until Filled
Investigating Chromatin Dysregulation due to Aberrant Dioxygenase Function in Human Pathology
A postdoctoral fellowship position is available in Dr. Abhishek Chakraborty’s newly established laboratory in the Department of Cancer Biology at the Cleveland Clinic. The laboratory is part of Cleveland Clinic’s Genitourinary (GU) Malignancies Research Center and has close ties to both basic researchers as well as GU clinicians at the Cleveland Clinic and the broader Case Comprehensive Cancer Center.
We are interested in the relevance of oxygen- (and 2-oxo-glutarate) dependent dioxygenases in cellular physiology, particularly in oxygen sensing and human disease. Two notable publications highlight our contributions in these areas: 1) the demonstration that the H3K27 histone demethylase UTX/KDM6A is a novel cellular oxygen sensor that directly links physiological oxygen availability to transcriptional readout [Chakraborty AA et al. Science. 2019 (363) 1217] and 2) studies on profound chromatin dysregulation in kidney cancer, which led to the identification of the H3K27 histone methyltransferase EZH1 as a targetable dependency in kidney cancer [Chakraborty AA et al. Science Transl Med. 2017 (398). pii: eaal5272].
Ongoing work in the laboratory, based on epigenetic analysis and high-throughput screening data, continues to develop our previous findings. The techniques/areas of interest in the laboratory are Biochemistry [Protein purification and Enzymatic Assays], Molecular Biology [Cloning, Western Blotting, etc], Proteomics, Cancer Biology [in vitro and in vivo tumor models], Cellular Metabolism [steady state and flux-balance analysis], Pharmacology [drug discovery and delivery], Genomic analysis [RNA-Seq and ChIP-Seq data], Genetic Screens [CRISPR/Cas9 and ORF-based libraries], and Pharmacological Screens [Drug-based libraries].
The ideal candidate would have a M.D., Ph.D., or a M.D./Ph.D. degree with interests and expertise in one or more of these areas. We desire a self-motivated candidate who has the ability to spearhead their research projects. A collaborative and collegial work ethic, a strong commitment to basic cancer research, and outstanding verbal and communication skills are all essential qualities in the applicant.
The position provides a unique opportunity to study chromatin function, tumor metabolism, molecular oncology, drug development, and clinical collaborations, in a world class clinical/research center.
Candidates with an interest in the position should email their CV and contact information for 3 references to:
Abhishek A. Chakraborty, Ph.D.
Dept of Cancer Biology
Lerner Research Institute
Cleveland Clinic, OH
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