Postdoctoral Fellow (Complement Sys. - Vacant Position for Vahid Afshar-Kharghan's Laboratory)

The University of Texas M. D. Anderson Cancer Center

Houston, TX

ID: 7071780
Posted: November 4, 2020
Application Deadline: Open Until Filled

Job Description

Position/Program Description:
This position will study the role of the complement system on the tumorigenesis and progression of cancer.
1. To design and conducts in vitro experiments on the role of complement proteins in cancer cell proliferation and morphological changes
2. To design and conducts in vitro experiments on the role of complement proteins in proliferation, differentiation, and polarization of T cells
3. To design and conducts in vivo experiments using mouse models of cancers to study the effect of the complement system in growth and metastasis of different cancers, and the therapeutic benefit of complement inhibitors on blocking tumor growth.
4. To conduct animal dissections and prepare tissue specimens from tumors for processing: fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, immunofluorescence microscopy, and in situ hybridization.
5. To perform imaging studies from tumor specimens: light microscope, immunofluorescence microscopy, and morphometric image analyses.
6. To conduct DNA, RNA, and protein extraction and purification.
7. To conduct DNA, RNA, and protein analysis by PCR, RT-PCR, Quantitative PCR, acrylamide gel electrophoresis, ELISA, and Western blotting.
8. To be up-to-date with the literature relevant to her project on complement biology and cancer immunology
9. To communicate freely and clearly, but also to be respectful to other lab members.
10. Records the experiments and results meticulously.
11. Analyze data, prepare graphs, figures, and help in writing and submitting the manuscript.

Learning Objectives:
- Learning to design and conduct experiments in vitro and in mouse models of cancer
- Learning to troubleshoot and analyze the generated data
- Learning important topic in complement biology, the immune response to the tumor, immune profiling tumor microenvironment, mouse genetics

Eligibility Requirements:
-Ph.D. in biological sciences
-Familiarity with murine studies
-Familiarity with basic laboratory techniques, such as flow cytometry, ELISA, Western blotting, PCR, RT-PCR, RNA, and DNA extraction



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