Postdoctoral Fellow

The University of Texas M. D. Anderson Cancer Center

Houston, TX

ID: 7073781
Posted: January 6, 2021
Application Deadline: Open Until Filled

Job Description

The Genomics Test Development Laboratory (GTDL) in the Department of Translational Molecular Pathology, develops new techniques for cancer genotyping in liquid biopsies, hematological malignancies and solid tumors; partners with the Molecular Diagnostic Laboratory (MDL) at MD Anderson to assess, optimize and validate novel molecular diagnostic tests to facilitate the cost-effective transfer of discovery markers and related assays into the CLIA environment.

The GTDL is interested in having a Post-doctoral fellow with a strong molecular biology background and a familiarity with Bioinformatics pipelines for Next Generation Sequencing (NGS) who will work to accomplish the goals of the laboratory. The primary purpose of the Post-doc is to design, optimize and perform new molecular assays geared for use in both the research and clinical space. This person would also help to facilitate the transition of translational research projects into the clinical lab and work closely with collaborators in different departments.

Key functions:
•Design, optimize, and validate new or existing genomic assays, including NGS, ddPCR, and gene expression by PCR, HTG, and NanoString for translational research or transfer into the CLIA environment.
•Works with internal and external collaborators (clinicians, vendors, faculty, staff, industry partners) to develop new molecular assays for the laboratory
•Assists in project planning and adheres to realistic timelines for implementation of assays in development.
•Works closely with Bioinformatics in the analysis and interpretation of NGS data and provides written reports to collaborators.
•Assists in the development of lab policies and procedures including assay Standard Operating Procedures (SOPs), assay transfer documentation and quality control procedures.
•Evaluates instruments, reagents and supplies for new and existing molecular assays
•Presents work at National conferences and for publication in peer-reviewed scientific journals

Desired skills:
•Hands on experience with NGS library preparation and sequencing platforms.
•Hands on experience in running different molecular assays including qPCR, ddPCR,
•NanoString and HTG.
•Experience with manual and automated nucleic acid extraction methodologies.
•Familiarity with Bioinformatics analysis for NGS and laboratory automation software.

Learning Objectives:

•​To understand the process of diagnostic test development.
•To apply the scientific method in the design and optimization of new molecular assays.
•To analyze data, write manuscripts for publication, present data/results at National and International conferences.
•To participate in the teaching/training of Research Assistants, graduate students and visiting fellows.
•To utilize the education and training opportunities within the department and the institution for career growth.

Eligibility Requirements:
​ An individual with a PhD in bioinformatics and/or computational biology from a reputed University/Institute with zero to one year of experience post-graduation is eligible. At least one first author publication in a peer reviewed journal stemming from PhD studies is required. The candidate must have independent thinking and be passionate about a career in academic science.

Program Dates:
Appointment will be for one year from date of hire.

Mentor Matching:
This position reports to Rajyalakshmi Luthra, Ph.D.

Diversity and inclusion at MD Anderson are not just important; they are essential. We take an expansive view of diversity, considering differences in race, ethnicity, sexual orientation, gender and religious beliefs, as well as communication styles, thought, skill and ambition. We constantly examine our culture to create an inclusive working environment that effectively attracts, retains, develops and utilizes the skills and talents of all employees. Our Diversity Council develops strategies to attract and retain superior talent and enhance workforce diversity and inclusion. We also offer multiple diversity training programs to our employees.


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