Research Associate/Post Doctoral Associate

University of Pittsburgh

Pittsburgh, PA

ID: 7074420
Posted: January 25, 2021
Application Deadline: Open Until Filled

Job Description

Lab Description:

Our lab is a growing group of life science/bioengineering undergraduates, medical students and surgical residents investigating strategies to ameliorate pathological fibrosis and promote regeneration of functional soft tissues. The lab's research efforts focus on exploring mechanisms through which adipose cells, including endothelial cells, stem cells and adipocytes, engage with immune cells and induce detrimental inflammation. We are developing novel in vivo chronic wound models and ex vivo organoid culture systems to identify disrupted cell signaling pathways that lead to chronic phagocyte activation and drive aberrant extracellular matrix production, tissue hardening and generation of reactive oxygen species. Our goal is to engineer therapeutic strategies to treat tissue fibrosis, dysfunctional wound healing and vascular inflammation in metabolic and neurodegenerative diseases.


Open Positions:

Multiple positions are open and include Research Associate and Postdoctoral Associates. The candidates should hold a PhD or/and MD degree within biology, cellular, molecular biology, biochemistry, immunology and/or physiology. Experience with cell culture, basic biochemical techniques, immunocytochemistry or immunological technology is essential. Experience with animal study is an advantage.

Candidates will have ample opportunities to acquire and develop new skills, work closely with the PI and collaborators while working in a supportive, highly collaborative, and energetic environment. State-of-the-art facilities are available within an exceptional research setting. We are a results-oriented group of highly motivated scientists who perform basic and translational research on dysfunctional soft tissue healing. Critical competencies include integrity, resourcefulness/initiative, good team player, enthusiasm & passion, decision making, and ability to acquire understanding and absorb information rapidly. Successful candidates must be able to generate new and creative approaches to problems. We’re always looking for people with those skills who thrive in teams and dynamic environments.

The position is open immediately although the start date is flexible. If interested, please submit CV to Dr. Kokai (kokail@upmc.edu). A final step in the hiring process is for candidates to arrange personal reference calls with former mentors or supervisors and others we may choose. Such insights from these former mentors will be used to facilitate individual development plans and maximize candidate growth as a lab member.





Position Definitions:

Research Associate: A full-time appointment in support of research and/or scholarship. The appointment is renewable and is not viewed as preparation for another position. Research Associates will have the Ph.D. or equivalent doctoral degree and will work under the supervision of the lab PI. The appointee is expected to assist with project development, research project topics in scientific literature and assist with manuscript preparation. Experience and quality of performance may justify an appointment or promotion to Senior Research Associate.

Postdoctoral Associate: A recent Ph.D. graduate seeking opportunities to continue development of his or her research skills, learn new research techniques, and work closely with the lab PI, Dr. Kokai. While developing their own professional skills, postdoctoral appointees are expected to provide significant contributions to the research enterprise, including the discovery and creation of new knowledge, and provide research direction to both undergraduate and graduate students. The appointee has the freedom and is expected to publish the results of his/her research during the period of appointment. Further, post-doctoral associates are expected to learn grantsmanship and seek Individual NIH Training Fellowships
Focus and Skillsets Developed:

• Adherent and non-adherent mammalian cell culture, including macrophages, adult stem cells, and induced pluripotent stem cells
• In vitro cell labeling, tracking and imaging with fluorescent, confocal and 2-photon microscopes
• Lipid raft protein analysis with Western blot and spectrometry-based proteomics
• Cell analysis and sorting with flow cytometry
• Developing novel drug encapsulation strategies




 

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