Postdoctoral Fellow – Rapid Manufacturing of Regenerative Heart Valves

The Wyss Institute for Biologically Inspired Engineering at Harvard University

Boston, MA

ID: 7076660
Posted: April 1, 2021
Application Deadline: Open Until Filled

Job Description

About the Wyss:

The mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University is to transform human healthcare and the environment by emulating the way nature builds. Developed as an alliance between Harvard and other premier academic and clinical partner institutions, Institute faculty and staff collaborate in high-risk, fundamental research and science-driven technology development. A major focus of the Institute is to translate the technologies developed by its faculty and staff into commercial products and therapies through collaborations with clinical investigators and establishment of corporate alliances.

Role Description:

Kevin Kit Parker’s Disease Biophysics Group at the Harvard University’s Wyss Institute for Biologically Inspired Engineering seeks a talented post-doctoral fellow to work on the rapid manufacturing of regenerative heart valves, or JetValves. The candidate will use the proprietary rotary jet spinning technologies developed in the Parker lab to design, build, and test heart valve replacements using natural and synthetic polymeric nanofibers. The goal of this translational project – which is part of an international collaboration with the University of Zurich in Switzerland – is to complete the preclinical characterization of JetValves in preparation for a first-in-man clinical trial.

In This Role You Will:

- Working together with a team of engineers, chemists, and applied mechanicians, the candidate will be responsible for nanofiber production and valve manufacturing, quality assessment, and structural and functional validation in vitro
- Perform standards tests using methodologies such as Instron®, FTIR, SEM, microCT, pulse duplicator testing, and cell infiltration
- Participate in the in vivo and post-mortem validation of JetValves implanted in sheep, including analysis of explanted samples via SEM and immunohistochemistry.


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