Research Fellow in Ion Channel Pharmacology

University of Leeds

Leeds, United Kingdom

ID: 7076694 (Ref.No. FBSBM1149)
Posted: April 2, 2021

Job Description

Are you an ambitious researcher looking for your next challenge? Do you have an established background in ion channel research? Do you want to further your career in one of the UKs leading research intensive Universities?

We are researching pharmacological treatments for KCNT1-associated childhood epileptic disorders, for which there is presently no effective therapy. KCNT1 mutations cause an increase in KNa1.1 potassium channel activity and we have used protein structure-based virtual screening to identify novel potassium channel inhibitors. The research builds on our previous work in this area (see Cole et al., 2020, iScience) and aims to identify candidate molecules for further development as a drug. We are looking for a candidate with experience in ion channel function or pharmacology who would like to apply their expertise in the discovery of potential treatments for a rare neurological disorder. The role, funded by Action Medical Research, will involve pharmacological characterisation of KNa1.1-inhibiting molecules using fluorescence microplate reader assays, manual and automated patch clamp electrophysiology. The successful candidate will play a key role in advancing our understanding of how compounds inhibit potassium channels and which chemical properties determine their potency and selectivity. Our interdisciplinary project team includes Dr Jonathan Lippiat (ion channel biology), Dr Katie Simmons (medicinal chemistry), and Dr Stephen Muench (structural biology). 

You should have a PhD (or close to completion) in ion channel research or a closely allied discipline with experience in patch clamp electrophysiology and mammalian cell culture.

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was awarded a Silver award in 2020.  We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information. 

Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Biological Sciences
School/Institute:  School of Biomedical Sciences
Category:  Research
Grade:  Grade 7
Salary:  £33,797 to £40,322 p.a.
Due to funding limitations it is unlikely an appointment will be made above £38,017 p.a.
Working Time:  37.5 hours per week
Post Type:  Full Time
Contract Type:  Fixed Term (2 years)
Release Date:  Wednesday 31 March 2021
Closing Date:  Wednesday 28 April 2021
Reference:  FBSBM1149

The University community is made up of a wide range of people with diverse backgrounds and circumstances, which we value and regard as a great asset. As part of our continued commitment to equality and inclusion, we strive to create an environment where everyone can reach their full potential and have a real opportunity to participate in and contribute to our activities.


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