Postdoctoral Fellow (Cancer Systems Imaging - Dr. Loukia Karacosta's Lab)

The University of Texas M. D. Anderson Cancer Center

Houston, TX

ID: 7076886 (Ref.No. 710509-00006)
Posted: April 12, 2021
Application Deadline: Open Until Filled

Job Description

The Department of Cancer Systems Imaging (CSI) is one of the largest new programs at The University of Texas MD Anderson Cancer Center within the Division of Diagnostic Imaging. The goal of this department and its research program is to develop new methodologies to visualize the cellular, biochemical, and genetic processes that contribute to the development and progression of cancer and to translate these discoveries into the clinic.

Dr. Loukia Karacosta's lab focuses on poorly characterized processes such as senescence and epithelial-mesenchymal transition (EMT) and aims to dissect how phenotypic plasticity drives the dynamics of drug resistance, therapy response and subsequent disease progression in the tumor microenvironment as a whole. By leveraging cancer systems biology approaches and single-cell technologies like mass cytometry (CyTOF), multiplexed imaging, live imaging and computational tools, we aim to interrogate the complex biology and spatiotemporal dynamics of therapy resistance in various cancer systems such as: cell lines, patient-derived organoids and tissue explants and longitudinal clinical specimens. The overall goal is to utilize innovative approaches of cancer systems biology to develop tools at the translational forefront of cancer systems research, towards predicting and counteracting mechanisms of drug resistance and evaluating – at a personalized level – disease status and response to treatment in cancer patients.​
Eligibility Requirements:
​Prospective candidates with a variety of backgrounds are welcome to apply with a Ph.D. in fields such as cancer biology, molecular and cellular biology, biomedical engineering, biochemistry, and computational biology/bioinformatics from an accredited institution of higher learning. The ideal candidate would have at least some prior experience in areas like cancer cell biology, cancer systems biology, preclinical cancer models, use of immortalized cell lines, organoids and tissues, analysis of advanced imaging techniques and single-cell data, computational biology or bioinformatics with interest in developing specialized skills in generating high-dimensional data and downstream analysis with translational applications. Although not required, expertise in single-cell analysis (e.g. CyTOF and RNAseq), multiplexed imaging and cancer systems biology is highly desirable.​

Diversity and inclusion at MD Anderson are not just important; they are essential. We take an expansive view of diversity, considering differences in race, ethnicity, sexual orientation, gender and religious beliefs, as well as communication styles, thought, skill and ambition. We constantly examine our culture to create an inclusive working environment that effectively attracts, retains, develops and utilizes the skills and talents of all employees. Our Diversity Council develops strategies to attract and retain superior talent and enhance workforce diversity and inclusion. We also offer multiple diversity training programs to our employees.

Contact Information:

Heidi L. Bradley
Cancer Systems Imaging
United States


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