Postdoctoral Fellow - Brenner Laboratory - Diabetes and Cancer Metabolism

City of Hope

Duarte, CA

ID: 7079623 (Ref.No. 10011474)
Posted: June 10, 2021
Application Deadline: Open Until Filled

Job Description

About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer, type 1 diabetes, type 2 diabetes and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

City of Hope has one of the most influential type 1 and type 2 diabetes research programs in the world. Our scientists' work has revolutionized the understanding and treatment of the disease and continues today with exciting developments in cell transplantation, gene regulation, immune tolerance and gaining systemic understanding of diabetes as a complex, multifaceted disease.

To learn more about our exciting research and accomplishments in the field of Diabetes, please visit https://www.cityofhope.org/research/diabetes-metabolism-research-institute

Position Summary

A postdoctoral fellowship opportunity is immediately available in the laboratory of Dr. Charles Brenner in the Diabetes and Metabolism Research Institute (DMRI) at Beckman Research Institute of City of Hope. The Brenner laboratory examines how nicotinamide adenine dinucleotide (NAD), the central regulator of metabolism, is disturbed by diseases and conditions including cancer, neuropathy, fatty liver, postpartum and viral infection. By identifying alterations in metabolism, we identify ways to sensitize and kill cancer cells, protect damaged nerves, and improve the repair capacity of damaged tissues.

The postdoctoral fellow will dissect mechanisms of transcriptional, post-translational and metabolomic alterations as a function of metabolic stress to better model and develop treatments for metabolic diseases and cancer and to support good health in the face of postpartum and viral challenges. Please read more information about the laboratory at http://brennerlab.net .

Applicants are encouraged to carefully read papers downloadable from https://www.brennerlab.net/curriculumvitae/ (eg. paper #129 on postpartum, #135 on glioma, or our recent work on coronavirus https://doi.org/10.1101/2020.04.17.047480 ). After reading one or more recent papers, applicants should propose a question, or an experiment related to work in the Brenner laboratory.

Basic education, experience and skills required for consideration:
  • PhD or equivalent doctoral degree is required.
  • Creative work as documented by peer reviewed publications.
  • Applicants are encouraged to carefully read papers downloadable from https://www.brennerlab.net/curriculumvitae/ (eg. paper #129 on postpartum, #135 on glioma, or our recent work on coronavirus https://doi.org/10.1101/2020.04.17.047480 ). After reading one or more recent papers, applicants should propose a question, or an experiment related to work in the Brenner laboratory.


Additional Information:
  • Interested candidates should include a letter describing past accomplishments and future research interests, a CV, and a question/experiment related to the work in Dr. Brenner's laboratory
  • For more information on Dr. Charles Brenner's research please visit here


City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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  • Posting Date: Jun 4, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job


City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.



 

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