Assistant Research Professor - Translational Oncology/T Cell Immunotherapy

City of Hope

Duarte, CA

ID: 7080989 (Ref.No. 10009305-1)
Posted: July 12, 2021
Application Deadline: Open Until Filled

Job Description

About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

A position is open for a highly motivated Assistant Research Professor with a record of research achievements and significant publications in the field of translational oncology, preferably chimeric antigen receptor (CAR) T cell immunotherapy and/or immuno-oncology. The person filling this position will lead a research team furthering the development and optimization of a novel CAR T cell therapy (Wang et al., Sci Trans Med, 2020; PMID 32132216), and will utilize multiple molecular, cellular, imaging techniques and model systems to better understand the fundamental biology underlying this CAR T cell immunotherapy, extending this therapy to other brain tumors and solid tumors, and optimizing new CARs incorporating this technology.

The ideal candidate will have experience in CAR T cell therapy or other immunotherapies, and/or cancer biology specifically related to brain tumors and other solid tumors. As the team leader, this person will also be expected to interact and collaborate with a large group of researchers focused on developing T cell therapies in a translational research environment across multiple malignancy types. The position will bridge the laboratories of Drs. Christine Brown and Michael Barish in the Beckman Research Institute ( https://www.cityofhope.org/research/beckman-research-institute/research-departments-and-divisions/immuno-oncology/christine-brown-lab )

Key Responsibilities include:
  • Effectively lead a research team and collaborate with a diverse group of scientists involved in immunotherapy.
  • Develop, optimize and characterize this and other novel CAR T cell designs for brain tumors and other solid tumors.
  • Conduct animal studies to evaluate CAR T cell therapy approaches in multiple mouse models of cancer.
  • Conduct high-dimensional analyses of primary tissues, including multiparameter flow cytometry, multiplexed immunohistochemistry, gene expression profiling, and immunohistochemistry.
  • Develop approaches to interrogate correlative samples across multiple CAR T cell clinical trials.
  • Prepare manuscripts and/or grant proposals is preferred, along with a publication record in peer-reviewed scientific journals.
  • Mentor graduate students, postdoctoral fellows, and other more junior scientists.


Basic education, experience and skills required for consideration:
  • Doctoral-level degree (PhD, MD, or similar) and at least 2-3 years research experience in the fields of immunology, immunotherapy, and/or cancer/brain tumor biology.


Preferred education experience and skills:
  • Experience in cancer immunotherapy, cell-based assays and animal models, and high-dimensional immunochemical analyses and gene expression profiling, is highly preferred.
  • Experience in writing manuscripts and/or preparing grant proposals is preferred.


City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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  • Posting Date: May 12, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job


City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.



 

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