Research Assistant I Lab

Harvard Medical School

Boston, MA

ID: 7081253
Posted: July 16, 2021
Application Deadline: Open Until Filled

Job Description

Job-Specific Responsibilities

The laboratory of Ting Wu, located in the Department of Genetics at Harvard Medical School, is recruiting a research technician to start immediately! This individual will work under specific direction on spatial omics projects involving genetics, molecular biology, chemistry, microscopy, bioinformatics, and quantitative image analyses. We are a fun, passionate, and collaborative group that develops and uses cutting edge tools to better understand the functional aspects of three-dimensional genome organization.

Background:

Our laboratory studies chromosome biology. Chromosome sequence, structure, and positioning plays a pivotal role in gene regulation, stability, and ultimately, disease. To better understand this interplay between chromosomes and biological functions, we apply cutting edge biochemical, optical, and computational tools. We are constantly developing technologies (Oligopaints) to interrogate chromosomes at all length scales, from diffraction limited (OligoFISSEQ) and down to super-resolution (OligoSTORM, OligoDNA-PAINT) in highly multiplexed ways (OligoFISSEQ + OligoSTORM). We are a multidisciplinary, diverse, curious, and chromosome loving bunch. Check out our website for more details (www.transvection.org).

Typical Duties:

1. Performing laboratory experiments utilizing a wide range of techniques (e.g. OligoFISSEQ, OligoSTORM, Oligopaints, FISH, immunofluorescence, PCR) and equipment (e.g. super-resolution and conventional microscopes, microfluidics, thermal cyclers).
2. Designing Oligopaint libraries using bioinformatic pipelines.
3. Performing chemical reactions to formulate new reagents (sequencing reagents, fluorophores).
4. Collecting data.
5. Analyzing data by using and developing image analysis software.
6. Processing, organizing, and summarizing data, reporting experimental results using a variety of scientific, word processing, spreadsheet, statistical software applications, and program platforms.
7. Assisting in the design of laboratory experiments, techniques, and protocols.
8. Performing routine logging and/or testing of samples.
9. Performing related laboratory maintenance, such as maintaining and cleaning equipment and ordering supplies.

Basic Qualifications

At least one year of related work experience in a molecular biology laboratory (relevant coursework may count towards experience).

Additional Qualifications and Skills

- Bachelor's degree in a science related field strongly preferred.
- Chemistry, Molecular Biology, Genetics, or similar discipline preferred but not required.

Demonstrated abilities in basic laboratory techniques helpful, but not required. These techniques include PCR, human tissue culture, fluorescence in situ hybridization (FISH), fluorescence microscopy, immunohistochemistry, as well as in situ sequencing, chemical labeling, and purification. Familiarity with bioinformatics and image analysis is desired, but not required. This may include Python, MATLAB, or R as well as ImageJ, Nikon Elements, Vutara SRX, or similar. Superior communications skills to enable close, collaborative work.

Working Conditions: Will be required to master and use safety procedures if working with hazardous materials.

Additional Information

This is a one-year term position from date of hire, with possibility of extension, contingent on work performance and continued funding for the position.

Harvard Medical School strives to cultivate an environment that promotes inclusiveness and collaboration among students, faculty and staff and to create new avenues for discussion that will advance our shared mission to improve the health of people throughout the world.



 

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