Postdoctoral Associate - Chanda Lab (Immunity and Pathogenesis)

Sanford Burnham Prebys Medical Discovery Institute

La Jolla, CA

ID: 7081254
Posted: July 16, 2021
Application Deadline: Open Until Filled

Job Description

Sanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health.

A Postdoctoral Associate position is immediately available in the Infectious and Inflammatory Disease Center (IIDC) in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program focused on understanding virus-host interactions using systems-levels approaches, particularly influenza A virus and SARS-CoV-2. The goal of the project is to identify viral and host determinants that contribute to disease severity. This position will be focused on investigation of virus-host interplay using high throughput functional genetic screening and follow-up studies using traditional cell and molecular biology- biochemistry approaches. The person filling this position will play an important intellectual, technical, and scientific role in leading these projects. Position is supported by NIH funding.

TO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter, CV, references and list of any publications or accomplishments.

The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions. Viruses are obligate pathogens, and therefore their survival is dependent upon their ability to exploit host cellular machinery. Concurrently, viruses must also successfully evade immune surveillance mechanisms, including first-line (innate) defense systems. Specifically, we are studying cellular proteins required for both influenza A and retrovirus/HIV infection. additionally, we are investigating novel molecules that regulate, or respond to, Pattern Recognition Receptor (PRR) signaling. Taken together, we aim to elucidate the repertoire of host proteins required for viral infection, and understand the molecular strategies adapted by these viruses as countermeasures to innate immune responses. The scientists in the Chanda lab are also looking to find known drugs that can inhibit the Covid-19 virus. The approach they are taking, known as drug repositioning, can cut development time dramatically. Since they are looking at FDA-approved drugs that are proven to be safe in humans, these medicines could rapidly get to people infected with the virus. If successful, drug repositioning will likely be the fastest path to find a therapeutic solution for the virus. Visit the Chanda lab website to learn more: http://labs.sbpdiscovery.org/centerandlabs/infectiousdisease/chandalab/Pages/Home.aspx

Primary Responsibilities

-Independent experimental designs and data analysis
-Carries out a wide range of molecular virology and biochemistry techniques
-Accurately documents experiments and data
-Contributes to writing of reports and manuscripts with increasing responsibility over time
-Works collaboratively across lab functions and train other junior lab staff as needed

Required Experience:
-Ph.D. degree in biological science is required
-Strong background in virology, molecular biology, and biochemistry
-Experience working with viruses is required
-BSL-3 experience is a plus

Knowledge, Skills and/or Abilities
-Demonstrated knowledge in relevant specialized disciplines
-The ability to work independently and to handle multiple projects and deadlines
-Demonstrated ability to work in an interactive and collaborative team
-Excellent presentation, verbal, and written communication skills
-Possess strong attention to detail, analytical, time management, organizational, and interpersonal skills
-Embody the Institute's core values of Commitment, Collaboration, Communication, Community and Compassion

The scientists at Sanford Burnham Prebys Medical Discovery Institute are making research breakthroughs in cancer, neuroscience, immunology, and children's disease. We are also at the forefront of finding solutions for emerging health threats such as COVID-19, where we are working to identify drugs that may help millions of people. During our more than 40 year history, we have established an NCI-designated Cancer Center, designed one of the most sophisticated drug discovery centers in the nonprofit world, and created global collaborations that are leading to preventions, treatments and cures to improve human health.

Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE.



 

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