Postdoctoral Fellow - Protein Engineering for Immunotherapy

City of Hope

Duarte, CA

ID: 7081281 (Ref.No. 10011405)
Posted: July 17, 2021
Application Deadline: Open Until Filled

Job Description

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

The Williams lab is looking for a highly motivated Postdoctoral Fellow to advance the meditope technology platform to create novel ADCs and tumor-activated biologics for immunotherapy. The successful candidate will be highly skilled in protein production (E coli and mammalian cells), protein purification using various chromatographic methods, and characterization (HPLC, SPR, ITC, Mass spec), and cell-based assays. Experience in animal tumor models is a plus. The ideal candidate will have a solid publication record, excellent communication skills (written and verbal) and outstanding record keeping. The primary goal is to translate these efforts into the clinic to cure cancer. Critically, City of Hope has all the infrastructure to make this happen including three GMP facilities.

Basic education, experience and skills required for consideration:
  • PhD in chemistry, biochemistry, protein chemistry, biochemical engineering or related field with 1 to 3 years of postdoctoral experience
  • Experience with protein production and purification
  • Fully versed in protein purification methods (HPLC, SPR, ITC, Mass Spec)
  • Excellent written and verbal communication skills
  • Good problem-solving skills
  • Ability to conduct independent research
  • Ability to supervise others and work effectively in a team

Additional Information:

City of Hope is a world leader in translational medicine, including synthesis of first synthetic gene, humanization of monoclonal antibodies and pioneering work in CAR T cells. These discoveries have led to some of the most important therapeutics in world including recombinant insulin for maintenance of type 2 diabetes and Rituxan, Herceptin, Avastin, etc. for the treatment of cancer. Building off these successes, City of Hope houses three FDA approved GMP facilities along with its 27 core facilities to rapidly advance discoveries.
  • For more information about Dr. Williams' research, please click here .
  • Please note, this is one of multiple openings available in Dr. Williams' lab.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.



  • Posting Date: Jul 15, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.


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