Postdoctoral Position in Air Pollution & Alzheimer’s Disease

Indiana University School of Medicine & the Stark Neuroscience Research Institute

Indianapolis, IN

ID: 7084230
Posted: August 30, 2021
Application Deadline: October 29, 2021

Job Description

The Laboratory of Dr. Michelle L. Block is currently accepting applications for a postdoc focused on discovering the molecular mechanisms underlying how air pollution impacts Alzheimer’s disease neuropathology. This position is an important component to the overall focus of the Block Lab, which is centered on how the peripheral immune response regulates normal central nervous system physiology and disease, with a focus on how environmental exposures impact these processes. This particular project will focus on the role of the Th2 Lung-Brain Axis in Alzheimer’s disease.

The position will explore how the pulmonary/peripheral immune response regulates the central nervous system response to both urban and indoor air pollution to impact Alzheimer’s disease. Murine and cell culture models of Alzheimer’s disease will be routinely used along with molecular biology, histochemistry, RNAseq, flow cytometry, and imaging techniques (confocal, 2-photon, fluorescence, and bright field microscopy) to address these key questions.

The lab is part of the Stark Neurosciences Research Institute (SNRI), which is a fantastic environment for neuroscience and neurotoxicology training that is home to an assortment of neuroscience, neuroimmunology, and Alzheimer’s disease researchers. In addition, the lab is located in the new Neuroscience Research Building, where animal colonies, the Confocal Microscopy core, the Flow Cytometry core, and many other resources are conveniently located on the same floor as the laboratory. Other cores are also located elsewhere in the neuroscience building, including Behavioral, NanoString, MRI, and RNAseq cores, which are available for all of the collaborative and translational research at SNRI.

To apply, please send a cover letter describing your research interests/relevant background, a curriculum vitae, 3 references, and relevant reprints/preprints of research articles to: Michelle L. Block, Ph.D. Department of Pharmacology and Toxicology, [email protected]

The successful applicant will be highly motivated, creative, and have a Ph.D. in Neuroscience, Immunology, or a related scientific field, such as Pulmonary Biology. Strong experience with imaging techniques, flow cytometry, and molecular biology is a plus. The candidate will manage projects, develop novel techniques, present findings at conferences, write manuscripts, and contribute to grant application preparation, where training/mentoring/active collaboration for these responsibilities is designed to advance scientific and career growth. Salary will be commensurate with experience.