Postdoctoral Fellow - Leukemia Cell Survival

City of Hope

Monrovia, CA

ID: 7085314 (Ref.No. 10007913-6)
Posted: September 15, 2021
Application Deadline: Open Until Filled

Job Description

Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions.

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow in the Department of Systems Biology. This lab studies drug resistance in leukemia and how the microenvironment contributes to this: leukemia cells can become resistant to drug treatment because they obtain support for their growth and survival from stromal cells in the bone marrow. This lab studies the molecules and mechanisms that are responsible for this type of drug resistance development.

This lab works with leukemia in tissue co-culture with stromal cells, cell imaging, retroviral or lentiviral transduction, Cas/CRISPR knockout, FACS, and mice. Candidates who are interested in following an academic career path, are self-motivated and enjoy the complexity of biological systems are especially encouraged to apply. It is important for us that you can work well with others.

Key Responsibilities
  • Participate in project planning, experimental design, data generation, data interpretation and evaluation, and communication of results related to our studies how leukemia cells escape eradication by drug treatment;
  • Communication of results includes acquiring manuscript writing skills and publishing papers on the obtained results in peer-reviewed journals;
  • Develop grant writing skills and participate in seminars, lectures, poster sessions and presentations at national meetings;
  • Provide guidance to junior lab members, develop new methods and protocols for research and assist with the development of other projects in the lab.

Basic education, experience and skills required for consideration:
  • A Ph.D. degree in life or biomedical sciences, or a related discipline is required;
  • Experience in working with hematopoietic cells in tissue culture.

Preferred education, experience, and skills:
  • Expertise in glycobiology is an advantage but not required.

Additional Information:
  • The location of the lab at the Monrovia Campus of the Beckman Research Institute within the Department of Systems Biology provides many opportunities to interact with others who study leukemias;
  • The lab also has ongoing collaborations in the area of glycobiology with scientists at the Institute for Glycomics, Griffith University, Australia;
  • For more information, please visit Dr. Heisterkamp's lab here: .
  • Please include an updated CV, a 1-page cover letter describing your current position, your reasons for applying and contact details of three recent referees as a single PDF.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


  • Posting Date: Sep 20, 2020
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.


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