ImmunAID Postdoctoral Research Fellow

University of Leeds

Leeds, United Kingdom

ID: 7086685 (Ref.No. MHLRM1168)
Posted: October 7, 2021

Job Description

Applications are invited for a Postdoctoral Research Fellow position in the research group of Professor Michael McDermott on a project funded by the Horizion 2020 entitled “Immunome project consortium for Autoimflammatory disorders (ImmunAID)

You will co-ordinate projects related to Work Package 3 (WP3) of ImmunAID programme entitled: “Inflammasome-associated pathways in sporadic and undiagnosed systemic autoinflammatory disorders (SAID)”. The overall goal of the tasks in WP3) is to assess the range of functions, dysfunction and biomarker potential of NLRP3 inflammasome complexes in SAID. Specifically, you will be working on task 3.3 of WP3 with the following aim:

*  To characterise negative regulators of NLRP3 inflammasome activation, including the effects of decoy proteins, encoding CARD-only proteins (COPs) and the related PYRIN domain-only proteins (POPs), that competitively bind to integral inflammasome components.

We are using standard laboratory-based methods to investigate NLRP3 inflammasome activation products and the unfolded protein response (UPR) in cells from patients with SAIDs and selected cell lines. A Seahorse Analyser is used to examine metabolic pathways and quantify mitochondrial ROS (mROS) production. Cryo-electron microscopy (Cryo-EM) and bioimaging is used for structural molecular biology in collaboration with the Astbury Centre (Leeds).

Reporting to Prof McDermott, your work will be carried out in collaboration with Dr. Sinisa Savic, capitalising on the infrastructure and samples collected through the Leeds Centre for SAIDs, based across St James’s University Hospital and Chapel Allerton Hospital. You will have access cells and sera (blood) from patients with genetically defined SAID and also those with sporadic or unknown causes. You will develop and validate assays for use in cell culture supernatants and biological fluids. Some of the work will be done in conjunction with the Protein Production Facility (run by Dr Brian Jackson) and the Centre for Biomolecular Interactions (run by Dr Iain Manfield), both located within the Faculty of Biological Sciences in the Astbury Centre for Structural Molecular Biology.

In combination with one other Postdoctoral Research Fellow, you will support the management of the research group, specifically dedicated to this project, as required.

The post will be based primarily in the Wellcome Trust Brenner Building at the St. James’s University Hospital site within the Institute of Rheumatic and Musculoskeletal Medicine.

To explore the post further or for any queries you may have, please contact: 

 Professor Michael McDermott, Professor of Experimental Rheumatology

Tel + 44 (0) 113 343 8641, Email: m.mcdermott@leeds.ac.uk.

 If you have any specific enquiries about your online application please contact Angela Greenbank, email: A.Greenbank@leeds.ac.uk

The University of Leeds is committed to providing equal opportunities for all and offers a range of family friendly policies. The University is a charter member of Athena SWAN and holds a Bronze award. We will be happy to consider job share applications and are committed to flexible working for all our employees.

Location:  Leeds - St James University Hospital
Faculty/Service:  Faculty of Medicine & Health
School/Institute:  Leeds Institute of Rheumatic & Musculoskeletal Medicine (LIRMM)
Category:  Research
Grade:  Grade 7
Salary:  £33,797 to £40,322 p.a.
Post Type:  Full Time
Contract Type:  Fixed Term (From start date to 17 March 2023)
Release Date:  Wednesday 06 October 2021
Closing Date:  Monday 25 October 2021
Reference:  MHLRM1168


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