Postdoctoral Fellow Position
Posted: October 13, 2021
Application Deadline: Open Until Filled
Job DescriptionProgram Description:
A postdoctoral fellow position is available in the Department of Cancer Biology under the direct supervision of Dr. Shabnam Shalapour. Research in the Shalapour Laboratory focuses on the role of chronic inflammation and adaptive immunity in control of tumor development and the response of various cancers to therapy. While the focus of the research is primarily based on tumor immunology and immunotherapy, our work also addresses fundamental questions in immunology, immunometabolism and cancer biology using cutting-edge technology tools including multicolor Flow cytometry, CyTOF, imaging, histology and large-scale omic analysis, e.g. single-cell RNA and ATAC-seq . We aim to understand how chronic inflammation induced by obesity, aging and alcohol abuse affect the immune system and thereby regulates its response to pathogens (bacteria and virus) and support tumor development. The focus then being how to use this information to not only prevent cancer development but also to develop novel therapeutic approaches to increase the response to immunotherapy and vaccination (see our recent publications; Nature. 2015 May 7;521(7550):94-8, J Clin Invest. 2015 Sep;125(9), Nature. 2017 Nov 16;551(7680):340-345.; Immunity. 2019 Jul 16;51(1):15-26, Annu Rev Immunol. 2020 Apr 26;38:649-671).
This postdoc fellowship will focus on the role of adaptive immune cells particular B cells in tumor immunology, and how chronic-inflammation regulate their development and effector function, using bioinformatic tools, genetically engineered mouse models (GEMM) and state-of-the-art immunological and experimental approaches.
Applicants must have a recent Ph.D. or M.D./Ph.D. degree in a related biomedical field with strong interests and self-motivation for research.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html