Research Fellow in Structural Biology

University of Leeds

Leeds, United Kingdom

ID: 7087842 (Ref.No. FBSMB1202)
Posted: October 26, 2021

Job Description

Are you an ambitious researcher looking for your next challenge? Do you have an established background in Structural Biology, particularly Cryo-Electron Microscopy (cryo-EM)? Do you want to further your career in one of the UKs leading research intensive Universities?

Based in the laboratories of Professor Alex Breeze and Dr Stephen Muench at the Astbury Centre for Structural Molecular Biology, you will join a vibrant cross-institution team with colleagues at University College London (UCL; Professor Matilda Katan lab), working together on an exciting project on the structural biology of cancer-associated variants of fibroblast growth factor receptors (FGFRs).

The project is funded for 3 years by the Medical Research Council (MRC) and will involve solving high-resolution structures of full-length receptor tyrosine kinase proteins and oncogenic gene fusions using cryo-EM, as well as investigation of novel complexes using NMR spectroscopy. Exceptional facilities and training are available in Leeds to support the project, including two Titan Krios electron microscopes equipped with the latest detectors as well as state-of-the-art cryoprobe-equipped NMR spectrometers including Bruker Avance III HD Aeon 950 MHz.

You should have a PhD (or close to completion) in structural biology or a closely allied discipline, with experience in cryo-EM or X-ray crystallography and potentially also NMR spectroscopy, as well as protein expression, purification and labelling for the study of large proteins. You will work closely with the second postdoctoral Research Fellow based at UCL, whose primary role will be to generate the protein samples for the cryo-EM investigations and to carry out cross-linking mass spectrometry studies with a collaborator at the Francis Crick Institute.

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was awarded a Silver award in 2020.  We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information.

To explore the post further or for any queries you may have, please contact:

Professor Alex Breeze, Professor of Biomolecular NMR

Tel: +44 (0)113 343 0087


Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Biological Sciences
School/Institute:  School of Molecular & Cellular Biology
Category:  Research
Grade:  Grade 7
Salary:  £34,304 to £40,927 p.a.
Due to funding limitations it is unlikely an appointment will be made above £37,467.
Working Time:  100%
Post Type:  Full Time
Contract Type:  Fixed Term (3 years - due to external funding.)
Release Date:  Monday 25 October 2021
Closing Date:  Sunday 14 November 2021
Reference:  FBSMB1202

The University community is made up of a wide range of people with diverse backgrounds and circumstances, which we value and regard as a great asset. As part of our continued commitment to equality and inclusion, we strive to create an environment where everyone can reach their full potential and have a real opportunity to participate in and contribute to our activities.