Staff Scientist - Translational Oncology and Immunotherapy

City of Hope

Duarte, CA

ID: 7092064 (Ref.No. 10010025)
Posted: June 9, 2022
Application Deadline: Open Until Filled

Job Description

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution.  AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities.  Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding.  We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

The Leo Wang Lab at City of Hope is hiring a staff scientist with expertise and interest in fundamental immune signaling to join our group in the Department of Immunooncology. We couple protein-focused molecular techniques (mass spectrometry, capillary Western blot, flow cytometry, CyTOF) with in vitro and in vivo disease models to define the molecular basis of chimeric antigen receptor (CAR) signaling and activation. We correlate these fundamental proteomic pathways with their functional consequences, and use this information to aid in the rational design of solid-tumor targeted CAR constructs with improved persistence and potency. To learn more about our research, visit:

Key Responsibilities include:

  • Design and lead projects focused on CAR T cell signaling in multiple model systems, using canonical TCR signaling as a conceptual framework.
  • Coordinate lab tasks and operations among multiple lab members, including ordering, inventory, and other essential lab functions.
  • Keep detailed and accurate logs of experimental design and primary data, analysis, and synthesis.
  • Prepare data presentations and manuscripts for publication.
  • Initiate and maintain collaborations with other labs.
  • Travel to meetings to represent the lab and to present new data.

Basic education, experience and skills required for consideration:

  • Ph.D. or equivalent degree and ≥5 years of postdoctoral experience
  • Core competencies include cell and molecular biology, flow cytometry, protein biochemistry, and mouse work. 
  • Must be able to generate data quickly and carefully, synthesize it to design new experiments, and communicate findings efficiently in manuscript form.
  • Must be able to design and execute scientific projects independently.
  • Ability to develop cohesive team relationships and manage teams.
  • Extensive prior experience in immunology or a closely related field.
  • Good English oral and written communication skills; must be able to prepare scientific manuscripts.
  • Ability to respond effectively to constructive feedback.

Preferred education, experience and skills:

  • Programming experience (R, Python), preferred.

Additional Information:

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

For more information on Dr. Leo Wang’s research, please visit here.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer.  All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.