Postdoctoral Fellow in Thoracic/Head and Neck Medical Oncology (Dr. Jonathan Kurie)
Posted: January 12, 2022
Application Deadline: Open Until Filled
Job DescriptionThe Kurie Laboratory in the Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, seeks to fill multiple postdoctoral positions. Our research focuses on the molecular mechanisms by which lung cancer cells generate a pro-metastatic tumor microenvironment, with three complementary areas of investigation: (1) a tumor cell-derived collagen modifying enzyme called lysyl hydroxylase 2 (LH2) that functions as a nodal regulator of fibrosis and immunosuppression; (2) Golgi-directed secretory processes driven by oncogene-induced transcriptional programs; and (3) epithelial-to-mesenchymal transition as a driver of fibrosis and immunosuppression in the tumor microenvironment.
Postdoctoral fellows will benefit from training in model development and characterization, including 2- and 3-dimensional cell culture models and autochthonous and orthotopic mouse models that recapitulate features of the TME in human cancers, and translating those findings to clinically and molecularly annotated human tumor tissue banks. Fellows will have educational and mentoring opportunities (e.g., pilot funding, grant-writing courses, and teaching and mentoring experience in our summer undergraduate and graduate internship programs) and extensive opportunities to gain presentation skills at weekly Kurie lab meetings, monthly departmental joint lab meetings, monthly meetings for our programmatic research groups (NCI-funded SPORE, CPRIT-funded MIRA), and annual conferences (e.g., Keystone, Gordon, Cold Spring Harbor, AACR).
Individuals who have completed a Ph.D. and have training relevant to the position. Qualified individuals will demonstrate the potential for research as evidenced by their peer-reviewed publications and funding. Background in cancer biology and expertise in the design and execution of cell culture and in vivo experiments that incorporate a variety of molecular and cellular techniques is desirable.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Jonathan Kurie, M.D.
Thoracic/Head and Neck Medical Oncology
1515 Holcombe Blvd, Unit 432