Post doctoral researcher in genetically engineered T cell therapies at the University of Pennsylvania
Posted: April 18, 2022
Application Deadline: Open Until Filled
Job DescriptionDr. Mason’s lab at the University of Pennsylvania’s School of Veterinary Medicine is seeking a full time post-doctoral researcher to join our young and enthusiastic group for a project focused on developing allogeneic CAR T cell therapies for cancer therapy. The overarching aim of the project is to understand the barriers to effective engraftment and survival of allogeneic CAR-T and devise strategies to enable the safe transfer and persistence of allo-CART. The successful candidate will utilize CRISPR/Cas9 editing and gene transfer technologies to generate triple edited T cells that express a second-generation CAR. In vitro and in vivo studies will be performed to assess effectiveness of editing on persistence and function. Client owned dogs with spontaneous cancer will be recruited to a clinical trial to evaluate safety and efficacy of this approach in the clinic and the successful candidate will also be engaged with evaluating immunological effects of allo-CART in this novel patient population. No prior experience with canine T cells is necessary.
We are seeking a motivated and talented immunologist to advance our canine CAR T cell program in collaboration with human CAR T cell laboratories at the University of Pennsylvania’s School of Medicine. The University of Pennsylvania provides a stimulating and academically rich environment and is a world leader in cancer immunotherapy. The close association of the veterinary and medical schools on campus provides ample opportunity for collaborative research between the two schools.
Qualifications: A doctoral degree (Ph.D. or MD/Ph.D or DVM/Ph.D.) in immunology or cellular and molecular biology is required. Relevant cellular and molecular biology skills including cell culture, genetic engineering, viral transduction, flow cytometry, and immune function analysis including cellular proliferation and cytotoxicity assays, ELISA, and ELISpot assays are required. Prior experience with cell-based therapies is desirable. The successful candidate must be fluent in English and have good scientific writing skills. Individuals with US citizenship or permanent residence are preferred.
The University of Pennsylvania is an equal opportunity employer that does not discriminate based on race, color, religion, sex or gender identity, age, disability, sexual orientation, or genetics. Salary and benefits are offered that are commensurate with NIH post-doctoral salaries.
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