Postdoctoral Fellow, Chemical Biology and Medicine Design

Pfizer Inc.

Cambridge, MA

ID: 7104457 (Ref.No. 4846256)
Posted: July 1, 2022
Application Deadline: Open Until Filled

Job Description


The Medicine Design group in Cambridge, MA is seeking a highly driven and innovative Ph.D.-level scientist to join our chemical biology group as a Postdoctoral Research Fellow in driving therapeutic innovation through technology development. This is a unique opportunity to be trained in the field of chemoproteomics, work collaboratively with diverse research teams within Pfizer, and publish in high-impact journals. By the end of the program, the postdoc will be proficient in designing chemical probes, photo-crosslinking, target engagement methodologies, mass spectrometry sample prep/data analysis and will be fully prepared to contribute to early-stage target engagement and target deconvolution studies. The ideal candidate should have strong background in organic chemistry, biochemistry, or chemical biology, and have a good understanding of biology and statistics.


Demonstrate strong technical and scientific rigor in project planning.

Proactively conduct literature searches to gather relevant information to form hypotheses for testing experimentally.

Design chemical probes and develop a novel target engagement methodology for studying compound interactions in a whole cell environment.

Desire to learn and help maintain nanoLC/mass spectrometers for conducting chemoproteomic experiments.

Generate and effectively communicate results regularly at internal meetings, make data-driven decisions to shape the direction of research project.


Basic Qualifications

Ph.D. in Chemistry, Biochemistry, Chemical Biology, or a related discipline is required

Ability and desire to work in a fast-paced, interdisciplinary scientific team

Strong problem-solving and analytical skills.

Excellent written and oral communication skills.

Proficient with data reporting and analysis software, as well as strong organizational skills.

Preferred Qualifications

Experience with photochemical crosslinking of compounds to proteins

Mammalian cell culture experience and affinity enrichment from live cells.

Familiarity with QExactive HF and/or Orbitrap Lumos Mass Spectrometers is desired but not required.


This position is a lab based position so candidate must be comfortable lifting, standing, sitting, walking, bending, ability to perform mathematical calculations, and ability to perform complex data analysis.


Eligible for Relocation Package

Eligible for Employee Referral Bonus

Must have Work Authorization in the United States

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.