RNA Accelerator Postdoctoral Fellow Gene Therapy

Pfizer Inc.

Cambridge, MA

ID: 7106568 (Ref.No. 4860965)
Posted: July 27, 2022
Application Deadline: Open Until Filled

Job Description

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Postdoctoral Fellowship in the pharmaceutical industry your focus will be related to design of vectors for AAV-based gene therapy. This Postdoctoral Fellowship will have daily interactions with Rare Disease Research Unit (RDRU) Biology and Gene Therapy groups as well as colleagues in other Pfizer disciplines in a supportive environment for rigorous scientific training. As a highly motivated, skilled and independent scientist, you will contribute to advancement of AAV drug design to treat various diseases. The position is based in Kendall Square, Cambridge MA.

How You Will Achieve It

Combine state-of-the-art approaches in the fields AAV-based gene therapy and in-born errors of metabolism to generate two peer-reviewed publications in high quality journals

Independently design, conduct, analyze and present in vitro and in vivo/ex vivo experiments
Establish ex vivo enzyme assays and perform in vivo AAV biodistribution and efficacy studies in animal models of disease
Fundamentally advance the understanding of disease mechanisms and biology
Attend and present at least one scientific conference per year to present findings and represent Pfizer’s commitment to research.
Engage and work with external collaborations and Contract Research Organizations (CROs).
QUALIFICATIONS

Must-Have

Recent Ph.D. in biological sciences
Track record of scientific achievements through publications and presentations.
Hands-on experience with in vivo rodent experimentation
Previous work with AAV required.
Experience in diverse molecular and biochemical laboratory techniques
Exceptional communication skills and demonstrated ability to work effectively as part of a team.
Nice-to-Have

Preferred experience in enzymology, dominant-negative diseases and liver metabolism

OTHER JOB DETAILS

Eligible for Relocation Assistance

Must Have Work Authorization in US

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.