Postdoctoral Fellow: Systems-Wide Protein Turnover Analysis With Mass Spectrometry Based Proteomics

Pfizer Inc.

Andover, MA

ID: 7111344 (Ref.No. 4846660)
Posted: September 21, 2022
Application Deadline: Open Until Filled

Job Description


An exciting postdoc position is available in the Biomedicine Design department at Pfizer, Andover for a highly motivated and driven PhD graduate with solid expertise in advanced mass spectrometry-based proteomics and associated bioinformatics tools. This role provides unique opportunities for development of novel and innovative mass spectrometry assays for large scale measurement of physiological protein turnover in human and preclinical species.

The successful applicant will develop and implement different sample preparation strategies from various tissue and biofluid matrices. Also, development of novel and intelligent targeted and non-targeted high resolution mass spectrometry methods and utilizing MS database search engine tools for protein identification and turnover measurement are in scope of the role. High impact publication in top tier journals is expected. Candidate will work with bioinformatics and translational modeling and simulation experts and has the opportunity to become familiar with translational sciences supporting drug development. This position requires solid technical expertise in high resolution LC-MS/MS, associated samples preparation and proteomics data analysis.


Responsible for the development of samples preparation techniques from various matrices and development of targeted and non-targeted high resolution mass spectrometry methods for proteome turnover analysis
Proactive engagement with the literature to use cutting edge science for novel and innovative methods to overcome challenges facing the project
As a strong collaborator seeking guides and communicates with colleagues and advisors for timely achievements of the goals and milestones
Use of bioinformatics and software tools for data analysis, interpretation and classification
Providing periodic progress reports and presenting at internal and external conferences or meetings and publishing at top tier journals

Ph.D. in chemistry, biochemistry or related disciplines is required
Expertise in development and implementation of assays based on protein mass spectrometry
Experience and knowledge in operation of modern high resolution ion trap/orbitrap and triple quadrupole mass spectrometers and associated control and data analysis software systems
Knowledge and application of complex sample preparation methodologies as applied to protein mass spectrometry workflows techniques including tissue preparation/bioanalysis, samples fractionation and immuno-analytical techniques
Good level of expertise in the relevant bioinformatics tools and software for mass spectrometry data analysis and interpretation


Lab based position requiring performing all typical laboratory related activities

Occasional travel to Cambridge (Kendal Square) is required, depending on project needs


Eligible for Relocation Assistance

Must have Work Authorization in the US

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.