Senior Staff Research Assistant

University of Oklahoma

Oklahoma, OK

ID: 7114788 (Ref.No. ta223016)
Posted: October 26, 2022
Application Deadline: Open Until Filled

Job Description

Job Description


The Laboratory of Biomolecular Structure and Function (LBSF) at the University of Oklahoma Health Sciences Center (OUHSC) seeks an experienced crystallographer to run the daily operations of the LBSF. The LBSF is part of a suite of core labs supported in part by the OUHSC Vice President of Research. The LBSF is also part of the Biomolecular Structure Core (BSC) for the Oklahoma Center of Biomedical Research Excellence in Structural Biology (OCSB). The OCSB has been the focal point of Oklahoma's structural biology community for ten years and was just awarded its phase III funding for five years. The community includes 50 labs at three major research institutions. The position is at the Senior Staff Research Assistant level. The position is expected to be long-term (> 5 years), pending the continued grant-funding success of the users of the LBSF. The candidate will be responsible for working with PIs to advance their structural biology projects. These efforts will include routine technical operations, developing new protocols to overcome challenging problems, and training the staff of user labs in protein purification, crystallization, data collection, and structure determination. The candidate has to have the ability to do all of the tasks in the crystal structure workflow and will often have to do this work alone when the user lab lacks available workers. The ideal candidate for this position will have a masters degree in biochemistry and two years of experience in macromolecular crystallography.


  • Collects various forms of data pertaining to the research project or projects
  • Conducts analyses of data
  • Interprets, draws conclusions, and discusses with principal investigator
  • Presents research material to fellow researchers and colleagues
  • Keeps record of information obtained during research
  • May include a database of information or hard files
  • Conducts research of the literature
  • Independently conducts technical research
  • Prepares various reports containing descriptive, analytical, and evaluative content that may be submitied for publication
  • Constructs tests or assists in the construction of tests
  • Collaborates with other researchers
  • Tracks time by project for monthly effort reports and biling of services rendered
  • Maintains a well-organized notebook
  • Available to users during the core lab's work hours
  • Has ability to work alone for extended periods
  • Checks crystallization trays on a schedule
  • Provides regular verbal and short written reports on progress to users
  • Provides training to users of the lab instruments and maintains lab instruments
  • Keep chemical inventory updated
  • May supervise a staff of research technicians and/or research assistants
  • Delegates tasks and oversees work
  • Performs various duties as needed to successfully fulfill the function of the position

Job Requirements


Education: Bachelor's Degree in a Biological Science, Chemistry, Physical Science, or related field.

Experience: 24 months research laboratory experience

Equivalency/Substitution: Will accept 48 months equivalent experience in the aforementioned fields in lieu of the Bachelor's Degree, for a total of 72 months combined research assistant/technician experience.


  • Working knowledge of how to handle biohazard materials or chemicals following Federal, State, and University regulations and guidelines
  • Detail oriented
  • Ability to analyze data and keep records
  • Ability to communicate verbally and in writing
  • Ability to supervise research technicians or assistants

Physical Requirements:

  • Physical: Standing for prolonged periods. Manual dexterity. Stoop, bend, crouch, or lift up to 25 pounds. Speaking and listening.
  • Environmental: Laboratory Environment. May be exposed to biohazardous materials, chemicals, odors, or carcinogens.


  • Ability to troubleshoot problems by reasoning with physical biochemical knowledge.
  • Assembly of growth media and buffers from scratch.
  • Assembly to work independent of molecular biology kits.
  • Plasmid DNA purification.
  • Molecular cloning with T4 Ligase.
  • Recombinant protein overexpression with ability to manually prepare gels.
  • Protein purification (affinity chromatography and size-exclusion column chromatography at a minimum).
  • Manual assembly of crystal optimization reservoir solutions for crystal optimization crystals.
  • Experience processing diffraction data.
  • Experience with structure determination and refinement.
  • Experience with preparing images for publication.

Equal Employment Opportunity Statement: The University of Oklahoma, in compliance with all applicable federal and state laws and regulations, does not discriminate on the basis of race, color, national origin, sex, sexual orientation, genetic information, gender identity, gender expression, age, religion, disability, political beliefs, or status as a veteran in any of its policies, practices, or procedures. This includes, but is not limited to, admissions, employment, financial aid, housing, services in educational programs or activities, and health care services that the University operates or provides.  

Diversity Statement: The University of Oklahoma is committed to achieving a diverse, equitable, and inclusive university community by recognizing each person's unique contributions, background, and perspectives. The University of Oklahoma strives to cultivate a sense of belonging and emotional support for all, recognizing that fostering an inclusive environment for all is vital in the pursuit of academic and inclusive excellence in all aspects of our institutional mission.