University of Michigan

Ann Arbor , MI

ID: 7121922
Posted: January 24, 2023
Application Deadline: Open Until Filled

Job Description


The Barmada & Mosalaganti Labs at the University of Michigan are looking for a postdoctoral research fellow to join their research team to establish faithful in vitro models of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). You will leverage these models to recapitulate and investigate disease-associated patterns of protein aggregation, uncovering basic mechanisms of disease and paving the way for new biomarkers.

The Barmada Lab has a long-standing interest in delineating the molecular underpinnings of ALS and FTD through a combination of neuroscience, molecular biology, genome engineering, longitudinal microscopy, and stem cell biology. In a complementary fashion, the Mosalaganti lab uses cryo-electron tomography, correlative light, and electron microscopy approaches to elucidate structure of disease-related protein complexes in situ.

As a postdoctoral fellow, you will have unencumbered access to state-of-the-art equipment and microscopes located in the Department of Neurology and at the Life Sciences Institute, including a Leica Stellaris cryo-confocal, an Aquilos2, a Titan Krios G4i (with K3, Bioquantum imaging filter, and phase plate), and an Oxford Nanoimager. You will report directly to Drs. Mosalaganti and Barmada.

Queries regarding the project must be directed to [email protected] or [email protected]

Mission Statement

Our mission at the Life Sciences Institute is to advance the understanding of the fundamental processes of life, and to pioneer new ideas to improve human health.

For more information on the Life Sciences Institute:

For more information on the Mosalaganti lab:

For more information on the Department of Neurology:

For more information on the Barmada lab:


Experimental responsibilities include:

Culture, maintenance and differentiation of human induced pluripotent stem cells
Primary cell isolation and culturing
PCR and quantitative reverse transcriptase (qRT)-PCR
Molecular cloning
Genome editing (i.e., CRISPR/Cas9)
Western blotting
Fluorescence microscopy
Quantitative data analysis of microscopy data
Non-experimental responsibilities will include:

Collaborate with students, postdoctoral fellows, and lab staff
Oversee the training of new lab members
Attendance and presentation at lab meetings and journal clubs
Write papers and participate in discussions with both labs
Required Qualifications*

PhD (or equivalent) in cell biology, genetics or related discipline.
2 years of experience in light and confocal microscopy (imaging/data processing)
1 year of experience with primary cultures or stem cells
Familiarity with computational biology and image based analyses
Familiarity with CRISPR/Cas9 and molecular biology/cloning
Work as a team player
Experience in structural biology
Additional Information

In addition to a career filled with purpose and opportunity, The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family and plan for a secure future. Benefits include:

Many choices for comprehensive health insurance
Dental and Vision Insurance
Life insurance
Long-term disability coverage
Flexible spending accounts for healthcare and dependent care expenses
Maternity and Parental Leave
Background Screening

The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks are performed in compliance with the Fair Credit Reporting Act.

Application Deadline

Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.