Postdoctoral Associate- Liver Disease
Baylor College of Medicine
ID: 7122626 (Ref.No. 14643-en_US)
Posted: February 2, 2023
Application Deadline: Open Until Filled
A postdoctoral position is available in the laboratory of Hamed Jafar-Nejad, M.D., at the Department of Molecular & Human Genetics, Baylor College of Medicine. The laboratory uses cell culture, Drosophila and mouse genetics to identify and characterize genetic modifiers of human developmental disorders, in hopes of shedding light on disease pathophysiology and establishing new therapeutic targets.
The lab has reported a mouse model for a developmental disorder called Alagille syndrome (ALGS; OMIM 118450), and has identified a number of dosage-sensitive genetic modifiers of the liver phenotypes in this model (Thakurdas et al, Hepatology, 2016; Adams et al, Hepatology, 2020, and unpublished). Building on these observations, the Postdoctoral Fellow will take the lead in an NIH-funded project to examine the genetic and transcriptional network involved in ALGS liver abnormalities and will examine the potential utility of these modifiers for developing therapies for ALGS and other cholestatic diseases. These studies are likely to provide fundamental insights into normal biliary development and biliary repair in disease contexts.
- Plans, directs and conducts specialized and advanced research experiments.
- Evaluates and analyzes data.
- Establishes new research protocols and procedures.
- Summarizes research findings and publish results in research journals.
- Maintains laboratory operations.
- MD or Ph.D. in Basic Science, Health Science, or a related field.
- No experience required.
- Experience in mouse genetics and mammalian cell culture is essential.
- Expertise in molecular biology and biochemistry is highly desired.
- The ideal candidate will be a highly motivated, recent graduate with a strong publication record.
Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
PD; CA; CH; SN
Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.