Research Associate - Comparative Molecular Biology

Baylor College of Medicine

Houston, TX

ID: 7127957 (Ref.No. 15086-en_US)
Posted: March 14, 2023
Application Deadline: Open Until Filled

Job Description

Summary

The Research Associate will perform research of an advanced nature under the general direction of the Principal Investigator, requiring skilled knowledge of fundamental techniques and practices related to genetics, genomics and molecular biology. The Aiden lab’s work is cutting edge and lies on the intersection of biology, computer science, physics and mathematics and its primary focus is exploring the three-dimensional structure of the human genome. The lab’s work has been featured on the cover of Nature, Science and Cell. Dr. Aiden and his team have been responsible for seminal advances in a diverse array of fields spanning molecular biology, polymer physics, mathematics, and others. These include the invention of three dimensional genome sequencing, and consequent discoveries of the mechanisms of genome compartmentalization (Lieberman-Aiden et al., Science, 2009; Lieberman Aiden, Science, 2011) and loop extrusion (Sanborn & Rao et al., PNAS, 2015); the first reliable, genome-wide maps of chromatin looping (Rao & Huntley et al., Cell, 2014, Rao et al., Cell, 2017); and the development of 3D genome surgery to modify genome folding using targeted mutations (Sanborn & Rao et al., PNAS, 2015).

Job Duties

  • Design, prepare and conducts functional genomics experiments such as Hi-C, RNA-Seq, ChIP- Seq, ATAC-Seq
  • Maintain, manipulate and occasionally establish mammalian cell lines (experience in mammalian cell culture is essential, experience with iPSC culturing and transformation as well as establishing primary fibroblast culture is preferred)
  • Maintain a large biological specimens repository, ensure long-term integrity and preservation of collection, which include genetic material and linked ancillary digital metadata, improve collection and storage protocols
  • Organize and prepare documentation necessary for specimen accession, including national and international permits and associated documentation
  • Respond to specimen requests, data inquiries, specimen photo requests etc
  • Participate in data analysis
  • Supervise and coordinate the activities of less experienced research staff and occasionally assist with grant writing
  • Participate in overseeing day-to-day laboratory operation and maintaining security protocols and standards

Minimum Qualifications

  • Master's degree in Basic Science or a related field.  Experience in lieu of degree will not be accepted.
  • Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.

Preferred Qualifications

  • Experience in basic fundamental molecular biology techniques (such as gel electrophoresis, Western blotting, PCR, qPCR, etc.)
  • Experience in mammalian cell culture and aseptic techniques
  • Experience with maintenance and establishment of primary fibroblast cell cultures, iPSC culturing and transformation strongly preferred
  • Experience in one or more of the following is strongly preferred: next generation sequencing library preparation; functional genomics (RNA-Seq, ChIP-Seq, ATAC-Seq)
  • Data analytic skills 

 

 

Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.

 

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

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Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.