Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve
The Senior Associate Scientist is responsible for supporting the manufacture of materials for viral strain change within the Vaccine Research and Development – Early Bioprocess Development group. The colleague will execute process activities required for the manufacture DNA template, RNA drug substance, LNP drug product, and critical reagents. The responsibilities include UF/DF, affinity chromatography, column packing, and testing and analysis of in-process samples using various bioanalytical methodologies. The colleague will be expected to summarize and evaluate study and purification results. Detailed and accurate documentation of laboratory work and presentation of results is required.

How You Will Achieve
Compliance with all Standard Operating Procedures (SOPs)

Complete all required trainings in compliance with departmental requirements and follow appropriate safety practices in the workplace

Plan, prioritize, and perform downstream processing of vaccine products and critical reagents

Protein A and Protein G purification of antibodies

Column packing of affinity columns

Perform in-process assays on vaccine products, process intermediates, and related experimental samples using biochemical/analytical tests

Collaborate with colleagues from partner groups in Vaccine Research and Development, including Bioprocess Fermentation, Analytical, and Formulation Development groups

Detailed, accurate, and timely documentation and review of experiments in a laboratory notebook

Qualifications
Must-Have

Prior experience with bioprocessing/purification

Experience running chromatography with AKTA systems using UNICORN software

Proficiency with personal computers including word processing, spreadsheets, PowerPoint and relevant scientific software is desirable

Strong verbal and written communication skills with attention to detail

Self-motivated and a positive attitude

Ability to learn new techniques, follow instructions, keep accurate records, and comply with SOPs

Proven ability to work independently in hands-on laboratory setting and collaborate as part of a team

Nice-to-Have

Knowledge and ability to independently execute purification/recovery activities

Proficiency in various techniques such as FPLC/HPLC, UV-Vis, and SDS-PAGE to isolate and/or characterize biomolecules