Postdoctoral Position in BRCA and Cancer Biology

Medical University of South Carolina

Charleston, SC

ID: 7214920
Posted: February 7, 2024
Application Deadline: Open Until Filled

Job Description

The department of Biochemistry & Molecular Biology at MUSC has an opening for a highly motivated and collegial Postdoctoral Fellow in the laboratory of Dr. Judit Jimenez Sainz. The Jimenez Sainz lab focuses on the Breast Cancer Susceptible Gene 1/2 (BRCA1/2) and the Partner and localizer of BRCA2 (PALB2), caretakers of genome integrity which mutated lead to high risk of breast, ovarian, prostate, and gastrointestinal and melanoma cancers. BRCA1/2 and PALB2 are fundamental players in the repair of double-strand breaks through their role in homologous recombination and replication to preserve DNA stability. Specifically, the lab is seeking to understand the impact of genetic variants in BRCA1/2 and PALB2 localization and functions to define cancer risk and response to therapy. A second goal of the Jimenez Sainz lab is to identify novel therapeutic strategies to sensitize tumor cells based on cellular mislocalization of BRCA1/2 and RAD51 (BRCA2 partner in homologous recombination). The third goal of the Jimenez Sainz lab is to define the factors involved in the crosstalk between homologous recombination and replication machinery upon platinum drugs and PARP inhibitors.
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