Postdoctoral Fellow or Staff Scientist - Cancer Epigenetics and Therapeutic Target Discovery

City of Hope

Monrovia, CA

ID: 7245202 (Ref.No. 10026233)
Posted: May 17, 2024
Application Deadline: Open Until Filled

Job Description

Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions.

  • For consideration, please email your resume to Dr. David Chenat [email protected]
  • Postdoctoral Fellow Pay Rate: $34 hr. - $37.55 hr. ($70,720-$78,099.63)
  • Staff Scientist Pay Rate: $38.67 hr. - $57.69 hr. ($80,442.62-$120,000)

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

Dr. David Chen's lab in Systems Biology is seeking a highly skilled and motivated Staff Scientist or Postdoctoral Fellow to join their dynamic team. Dr. Chen is a distinguished leader serving as the Director of the Division of Epigenetics and Transcriptional Engineering at City of Hope Cancer Center. His lab investigates epigenetic mechanisms of drug resistance and identifies therapeutic targets in various cancers through cutting-edge techniques such as high-throughput genetic screens (recent papers: PMID: 38316881, 38394203, 37075745, 36563143, 34373586, 34210975).

For more information about Dr. Chen’s lab, please visit here.

As a successful candidate, you will:

  • Be involved in cancer genetics and epigenetics studies.
  • Contribute to wet-lab (experimental) and/or dry-lab (computational) research.
  • Utilize the cutting-edge CRISPR gene editing and screen approach to dissect cancer mechanisms.
  • Combine multiomics tools (RNA-seq, ATAC-seq, ChIP-seq, single-cell sequencing, mass spectometry, etc.) and 3D protein structural analyses.
  • Perform in vitro (cell culture) and in vivo (xenograft and PDX) cancer disease modeling.
  • Participate in novel technology development, including CRISPR gene tiling, single-cell CRISPR screens, etc.
  • Focus on cancer types including leukemia, lymphoma, GBM, breast cancer, HCC, Ewing sarcoma, etc.
  • Collaborate with other researchers in the lab for multiple publications.

Your qualifications should include:

  • Postdoctoral Fellow: A Ph.D. degree in life or biomedical sciences or a related discipline - cancer biology, structural biology, computational biology, bioinformatics, etc.
  • Staff Scientist: The Staff Scientist must possess, at a minimum, the U.S. equivalent Bachelor’s or Master’s degree in an appropriate discipline, and will often have a Ph.D. or other doctoral level degree.
  • Good oral and written communication skills in English.

Preferred qualifications:

  • Ph.D. and experience in bioinformatics, transcriptomic, proteomic, epigenetic, molecular dynamic, protein purification, compound screen, molecular cloning, or protein structural data analysis.

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here.

To learn more about our Comprehensive Benefits, pleaseCLICK HERE.


The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.

City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.