Postdoc/Assistant Staff Scientist - Bioinformatics

Oklahoma Medical Research Foundation

Oklahoma City, OK

ID: 7255781 (Ref.No. 5335833)
Posted: June 17, 2024
Application Deadline: Open Until Filled

Job Description

Overview
Founded in 1946, the Oklahoma Medical Research Foundation (OMRF) is among the nation's oldest, most respected independent, nonprofit biomedical research institutes. OMRF is dedicated to understanding and developing more effective treatments for human diseases, focusing on critical research areas such as Alzheimer's disease, cancer, lupus, Multiple Sclerosis, and cardiovascular disease. OMRF follows an innovative cross-disciplinary approach to medical research and ranks among the nation's leaders in patents per scientist.

Located in Oklahoma City, a city that offers a dynamic and flourishing downtown area, with low cost of living, short commute times and a diversified economy, OMRF has been voted one of the Top Workplaces since the inception of the award. This achievement has been accomplished thanks to OMRF individuals who share a unified understanding that our excellence can only be fully realized with a commitment to diversity, equity, and inclusion. Successful candidates will demonstrate commitment to these values.

Benefits
We offer competitive salaries and comprehensive benefits including, medical, dental, and vision insurance, minimum 8% company retirement contribution, vacation and sick leave, paid holidays, onsite cafe, free onsite fitness center with access to personal trainer, free parking and much more! Relocation assistance available for those located 50 miles outside of Oklahoma City metro and out of state. Learn more about our benefits here.

OMRF is an Equal Opportunity/Affirmative Action/Veterans Employer. All qualified applicants will receive consideration for employment without regard to gender, sexual orientation, gender identity, race, color, national origin, age, religion, disability, veteran status, or any other legally protected characteristic.


Responsibilities
The Nath Lab is seeking a highly motivated, self-driven, hardworking, and organized team player to join our efforts as a Post-doctoral Fellow or Assistant Staff Scientist in understanding the genetic mechanisms of lupus, an autoimmune disease. Using whole genome searches, the Nath Lab has identified several genes and genetic variants associated with lupus susceptibility. They are also following up on several genetic loci with experiments to understand the specific functional effects of these lupus-associated genetic variants, using cell lines and patient-derived primary immune cells or tissues. This involves applying various modern techniques for studying features of three-dimensional (3D) genomic organization, such as 3C, Hi-C, ChIP-Seq, and genome editing using CRISPR/Cas9. The role involves analyzing human genetic and genomic data and developing computational methods, requiring a blend of computational skills, statistical knowledge, creativity, and biological insight. Key tasks include identifying novel therapeutic targets and biomarkers by investigating human genetic variation (GWAS, Next Gen Sequencing) and integrating GWAS summary results with other data types like eQTL, mQTL, and functional genomic annotations. The candidate will also estimate heritability, perform Mendelian Randomization, and conduct fine mapping.

*This position is temporary, but has the potential to become a permanent role.*


Qualifications
Applicants should have a Ph.D., M.D., or M.D./Ph.D. (or expect to receive a doctoral degree soon). The successful candidate will investigate the functional effects of lupus-associated genetic variants identified through whole genome searches, utilizing cell lines and patient-derived primary immune cells or tissues.  Collaboration with experimental and clinical scientists to address specific target mechanism questions with genomic insights is essential. This position demands a highly motivated, self-driven individual with excellent teamwork and organizational skills. 


To apply, visit https://careers-omrf.icims.com/jobs/1719/postdoc-assistant-staff-scientist/job?in_iframe=1

OMRF’s excellence can only be fully realized by individuals who share our commitment to diversity, equity and inclusion. Successful candidates will demonstrate commitment to these values. OMRF is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to gender, sexual orientation, gender identity, race, color, national origin, age, religion, disability, veteran status or any other legally protected characteristic.